Of particular note is fluvoxamine, which is a potent CYP1A2 inhibitor and also inhibits other CYP enzymes, such as CYP2C19, CYP3A4. Cytochrome P 1A2 (abbreviated CYP1A2), a member of the cytochrome P Inhibitors of CYP1A2 can be classified by their potency, such as. Cytochrome P CYP1A2 Inhibitors. All categories. Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P .
Drug, Drug Name, Drug Indication. DB, Fluvoxamine, Indicated predominantly for the management of depression and for Obsessive Compulsive Disorder. Inhibition of cytochrome P (CYP) is a major cause of herb–drug interactions. The CYP1A2 enzyme plays a major role in the metabolism of. Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine.
Recently I learned of the potent CYP1A2 induction effects of proton-pump inhibitors (ie. omeprazole etc). These medications can significantly reduce olanzapine. enzyme.1 Drugs metabolized by CYP1A2 are called CYP1A2 substrates. CYP1A2 Inhibitors. Drugs that inhibit CYP1A2 will pre- dictably increase the plasma. Click on the product name to view detailed information such as the chemical structure and specific chemical properties for each of our CYP1A2 Inhibitors. A commonly used probe substrate for CYP1A2 activity is caffeine. .. juice ( enzyme induction); and (iii) the antidepressant fluvoxamine (CYP1A2 inhibition).
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